Subacute/Subchronic Toxicity Testing
Subacute toxicity is assessed after single or multiple exposures to extracts of device materials. The exposure period is longer than typical acute toxicity tests, but not to exceed 10% of the animal’s lifespan.
Subchronic toxicity is assessed after repeated intravenous injections of the device materials extract. These studies involve expanded evaluations and can include systemic changes, local irritation, body weight, blood values and tissue changes as part of the protocol. The length of time for the test and the parameters evaluated will depend on the end use of the device.